Vitamin E (mixed tocopherols) and Warfarin: interaction, severity and spacing
Vitamin E (mixed tocopherols) and Warfarin interact because high-dose alpha-tocopherol inhibits platelet aggregation and vitamin K-dependent clotting, adding to warfarin’s effect. Take them with care. Moderate risk.
The interaction in detail
| Pair | Vitamin E (mixed tocopherols) and Warfarin |
|---|---|
| Type | Nutrient–drug interaction |
| Severity | Moderate |
| Required spacing | None specified |
| Onset | At the time of dosing |
Mechanism
High-dose alpha-tocopherol inhibits platelet aggregation and vitamin K-dependent clotting, adding to warfarin’s effect.
What to do
Keep vitamin E below 400 IU per day on warfarin, and tell your prescriber if you start it.
How to fit both into one day
Vitamin E needs dietary fat for absorption and works with selenium. Keep it under 400 IU if you take an anticoagulant.
An evening dose is conventional so the INR drawn the next morning reflects a stable interval. Keep vitamin K intake consistent.
Putting Vitamin E (mixed tocopherols) in the midday and Warfarin in the evening satisfies the 0-hour separation without disrupting either one's absorption window.