What does Glutathione interact with?

Glutathione interacts with Vitamin C at a synergy level. The most significant pairing on record involves Vitamin C: Pair supplemental glutathione or NAC with vitamin C.

What happens if I take too much Glutathione?

No upper limit has been established, which reflects self-regulating absorption rather than unlimited safety.

Should I take Glutathione with food?

Glutathione does not have a strong food dependency, though taking it with a meal reduces stomach upset.

Other compound

Glutathione

Glutathione has no established recommended dietary allowance. It works best alongside Vitamin C and NAC (N-acetylcysteine).

Last reviewed: 2026-09-20Reviewed by: StackingRight clinical reviewPrimary source

What Glutathione does

Master intracellular antioxidant and cofactor for phase II detoxification.

No RDA established. Oral bioavailability is limited; NAC is a common precursor.

How much you need

Reference intakes for Glutathione in adults
Measure	Adult male	Adult female
Recommended intake	Not established	Not established
Upper intake level	None established
Typical supplement dose	600-1200 mg

Interactions involving Glutathione

2 sourced rules

Interaction rules involving Glutathione
Pair	Severity	Mechanism	Action
Vitamin C × Glutathione	Synergy	Vitamin C helps maintain glutathione in its reduced form and spares it during oxidative stress; oral glutathione absorption is also improved by vitamin C.	Pair supplemental glutathione or NAC with vitamin C.Source
NAC (N-acetylcysteine) × Vitamin C	Synergy	NAC supplies cysteine for glutathione synthesis, while vitamin C supports the enzyme systems that keep glutathione reduced.	Take NAC with vitamin C, ideally away from a protein-heavy meal.Source

Questions people ask about Glutathione

Sources

https://pubmed.ncbi.nlm.nih.gov/30578882/