Vitamin
Vitamin B6
Vitamin B6 requires 1.3 mg daily for adult women and 1.3 mg for men. The tolerable upper intake level is 100 mg. It works best alongside Vitamin B6 (P5P) and Vitamin B12 sublingual.
What Vitamin B6 does
Cofactor for neurotransmitter synthesis and haemoglobin formation.
Sustained intakes above the UL cause reversible sensory neuropathy.
How much you need
| Measure | Adult male | Adult female |
|---|---|---|
| Recommended intake | 1.3 mg | 1.3 mg |
| Upper intake level | 100 mg | |
| Typical supplement dose | 1 capsule · 25-50 mg | |
Interactions involving Vitamin B6
3 sourced rules| Pair | Severity | Mechanism | Action |
|---|---|---|---|
| Vitamin B6 (P5P) × Levodopa | Moderate | Pyridoxine accelerates peripheral decarboxylation of levodopa, reducing how much reaches the brain — unless carbidopa is co-prescribed. | Keep B6 under 25 mg per day unless carbidopa is part of your regimen.Source |
| Vitamin B6 (P5P) × Magnesium glycinate | Synergy | Pyridoxal-5-phosphate increases cellular magnesium retention, so the two work better together than either alone. | Taking B6 with magnesium is well tolerated and may improve magnesium status.Source |
| Vitamin B12 sublingual × Vitamin B6 (P5P) | Synergy | B6, B12 and folate are interdependent in one-carbon metabolism; correcting one without the others can leave homocysteine elevated. | Take the B vitamins together rather than in isolation — a B-complex covers this automatically.Source |