Question 1

Do Selenium and Vitamin E (mixed tocopherols) interact?

Accepted Answer

Yes. Selenium is the catalytic centre of glutathione peroxidase, which regenerates oxidised vitamin E. Each depends on the other for full antioxidant recycling. This is classified as a synergy interaction. Take selenium and vitamin E together; a common ratio is 100-200 mcg selenium to 200-400 IU vitamin E.

Question 2

Do I need to separate Selenium and Vitamin E (mixed tocopherols)?

Accepted Answer

No fixed interval is required. Take selenium and vitamin E together; a common ratio is 100-200 mcg selenium to 200-400 IU vitamin E.

Question 3

What is the mechanism behind the Selenium and Vitamin E (mixed tocopherols) interaction?

Accepted Answer

Selenium is the catalytic centre of glutathione peroxidase, which regenerates oxidised vitamin E. Each depends on the other for full antioxidant recycling.

Question 4

Should I stop taking Selenium or Vitamin E (mixed tocopherols)?

Accepted Answer

Not on the basis of this interaction alone. Restructuring timing is usually the right response: Take selenium and vitamin E together; a common ratio is 100-200 mcg selenium to 200-400 IU vitamin E. Talk to your physician or pharmacist before stopping anything prescribed.

Question 5

How strong is the evidence for this interaction?

Accepted Answer

This rule is derived from the NIH Office of Dietary Supplements reference material. The source is linked on this page so you can read it directly.

Question 6

What happens if I ignore this interaction?

Accepted Answer

You lose the benefit of the pairing rather than risking harm. Take selenium and vitamin E together; a common ratio is 100-200 mcg selenium to 200-400 IU vitamin E.

Pair	Selenium and Vitamin E (mixed tocopherols)
Type	Nutrient interaction
Severity	Synergy
Required spacing	None specified
Onset	At the time of dosing

Selenium and Vitamin E (mixed tocopherols): interaction, severity and spacing

The interaction in detail

Mechanism

What to do

Selenium and Vitamin E (mixed tocopherols): common questions